2.1 . Dosage Calculator Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Minor/Significance Unknown. This topic . Applies only to oral form of both agents. Minor/Significance Unknown. Am J Hosp Pharm. Below the form there are further instructions on how to use the calculator. Iron Deficit - Multi-Calc - GlobalRPH - Medical Calculators, Clinicians Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Deferasirox chelates iron. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Dosage form: injection, solution iron sucrose, benazepril. Iron Injection Administration | INJECTAFER HCP LBW = Lean body weight in kg. Applies only to oral form of both agents. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Initial infusion rate. Fulminant symptoms may include general paleness, confusion or episodes of passing out. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Either increases effects of the other by pharmacodynamic synergism. Applies only to oral form of both agents. Monofer 100mg/ml solution for injection/infusion - Summary of Product Applies only to oral form of both agents. Recommended dosing and infusion rates for PI. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. Applies only to oral form of both agents. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. In the text below the tool there is more information on how the iron deficit is calculated. DailyMed - VENOFER- IRON SUCROSE injection, solution The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Controlled studies in pregnant women show no evidence of fetal risk. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. 2015: 763576. Modify Therapy/Monitor Closely. Venofer may cause clinically significant hypotension. All Rights Reserved. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. We comply with the HONcode standard for trustworthy health information. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Applies only to oral form of both agents. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. This calculator will help pinpoint potential causes of anemia based on Fatal reactions have followed the test dose of iron dextran injection. Applies only to oral form of both agents. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. David McAuley, Pharm.D. Parenteral iron dextran therapy. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. We'll do this entirely for free, as long as the calculator has applications for women's health. A: Generally acceptable. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. 1990 Feb;24(2):162-6. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. This information does not assure that this product is safe, effective, or appropriate for you. You will have to pay for your IV iron. Use Caution/Monitor. Do not double the dose to catch up. commonly, these are "preferred" (on formulary) brand drugs. Use Caution/Monitor. Anemia; 2015: 763576. PDF Iron dosing and administration in adults backgrounder Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Parenteral iron dose - UpToDate This drug is available at a middle level co-pay. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . PDF Venofer - Food and Drug Administration Ren Fail. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. We have found the lower dose to be better tolerated in the second half of gestation. Minor/Significance Unknown. Avoid or Use Alternate Drug. official version of the modified score here. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Interaction only with oral iron administration. Applies only to oral form of both agents. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Applies only to oral form of both agents. Applies only to oral form of both agents. FERAHEME met the predefined criteria for non-inferiority to Venofer . Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Applies only to oral form of both agents. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Formula for calculating the required dose of iron sucrose Schrier SL, Mentzer WC, Landaw SA. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Applies only to oral form of both agents. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Applies only to oral form of both agents. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Use Caution/Monitor. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Administer on 5 different occasions over a 14 day period. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Copyright 2021 GlobalRPH - Web Development by. US residents can call their local poison control center at 1-800-222-1222. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. 2. Accessed: 4/12/2011. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). The elemental iron product used is Iron sucrose 20 mg/mL. Administer Venofer early during the dialysis session (generally within the first hour). Avoid or Use Alternate Drug. Applies only to oral form of both agents. May increase risk of hypotension. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. This drug is available at a higher level co-pay. Do Not Copy, Distribute or otherwise Disseminate without express permission. Most Iron Deficiency Calculator DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. PDF PRODUCT MONOGRAPH - pdf.hres.ca Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Applies only to oral form of both agents. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Copyright(c) 2023 First Databank, Inc. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. 1. Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. This cost includes the fee charged by the pharmacy. Kumpf VJ. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Use Caution/Monitor. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. commonly, these are "non-preferred" brand drugs or specialty For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Adding plans allows you to compare formulary status to other drugs in the same class. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. ANNA J. Avoid or Use Alternate Drug. Minor/Significance Unknown. 3. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Applies only to oral form of both agents. Minor/Significance Unknown. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Intravenous iron-dextran: therapeutic and experimental possibilities. Applies only to oral form of both agents. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Medicinal forms In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Ferric carboxymaltose (Ferinject) for iron-deficiency anaemia Baloxavir may bind to polyvalent cations resulting in decreased absorption. Applies only to oral form of both agents. Separate dosing of tetracyclines from these products. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Pregnancy: Risk Summary-Clinical Considerations. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Minor (1)iron sucrose, benazepril. Either decreases levels of the other by inhibition of GI absorption. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Administer Venofer only intravenously by slow injection or by infusion. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Corrected Calcium. Venofer has not been studied in patients younger than 2 years old. Applies only to oral form of both agents. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Each mL contains 20 mg of elemental iron. Iron Sucrose - SlideShare 1. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Use Caution/Monitor. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Human studies not conducted. Avoid or Use Alternate Drug. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Separate by 2 hr. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Applies only to oral form of both agents. Your doctor will do laboratory tests to monitor your response. Applies only to oral form of both agents. Kumpf VJ, Holland EG. Jacobs P, Dommisse J. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Information last revised December 2022. 1996 Aug;11(4):139-46. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. PDF Protocol for the use of Intravenous Iron Sucrose (Venofer Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. Mean change in Hgb from baseline to Week 5 2,5 Applies only to oral form of both agents. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Written by ASHP. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Chandler G, Harchowel J, Macdougall I. Avoid or Use Alternate Drug. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Iron sucrose: 20 mg/mL. You can further save the PDF or print it. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. 1 ,*. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Treatment of anemia due to iron deficiency. 2010; 193(9):525-32. Administer Venofer early during the dialysis session (generally within the first hour). Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW provider for the most current information. The dosage of Venofer is expressed in mg of elemental iron. Minor/Significance Unknown. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. Generic name: IRON SUCROSE 20mg in 1mL Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Applies only to oral form of both agents. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Each mL contains 20 mg of elemental iron. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. To view formulary information first create a list of plans. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Kidney Int. Applies only to oral form of both agents. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. . Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days.